AI Article Synopsis
- - The study investigates the connection between plasma and urinary vitamin C levels in individuals with diabetes, emphasizing those showing signs of renal leakage of the vitamin.
- - Through a retrospective analysis of clinical data, researchers found significant differences in health characteristics among those with renal leak, those with low vitamin C levels but no leak, and those with normal levels.
- - The findings suggest that renal leak of vitamin C is prevalent in the diabetic population studied and may play a role in cases of hypovitaminosis C among participants, particularly those with type 2 diabetes.
Article Abstract
Background: Hypovitaminosis C has negative health consequences. People with diabetes and hypovitaminosis C may fail to conserve vitamin C in the urine, thereby displaying evidence of inappropriate renal leak of vitamin C. This study describes the relationship between plasma and urinary vitamin C in diabetes, with a focus on the clinical characteristics of participants with renal leak.
Methods: Retrospective analysis of paired, non-fasting plasma and urine vitamin C, and also clinical characteristics, from participants with either type 1 or type 2 diabetes, recruited from a secondary care diabetes clinic. Plasma vitamin C thresholds for renal leak have been defined previously as 38.1 µmol/L for men and 43.2 µmol/L for women.
Results: Statistically significant differences in clinical characteristics were seen between those with; i) renal leak (N = 77) and; ii) hypovitaminosis C but no renal leak (N = 13) and; iii) normal plasma vitamin C levels (n = 34). Compared to participants with adequate plasma vitamin C levels, participants with renal leak tended to have type 2 (rather than type 1) diabetes, a lower eGFR and a higher HbA1c.
Conclusion: In the diabetes population studied, renal leak of vitamin C was common. In some participants, it may have contributed to hypovitaminosis C.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982671 | PMC |
| http://dx.doi.org/10.1016/j.jcte.2023.100316 | DOI Listing |
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