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Transungual Penetration and Antifungal Activity of Prescription and Over-the-Counter Topical Antifungals: Ex Vivo Comparison.
Dermatol Ther (Heidelb)
September 2024
Case Western Reserve University, Cleveland, OH, USA.
Introduction: Topical antifungals for toenail onychomycosis must penetrate the nail to deliver an inhibitory concentration of free drug to the site of infection. In two ex vivo experiments, we tested the ability of topical antifungals to inhibit growth of Trichophyton rubrum and Trichophyton mentagrophytes, the most common causative fungi in toenail onychomycosis.
Methods: Seven topical antifungals were tested: three U.
Psoriasis Vulgaris Masked by Tinea Pedis in Two Unhoused Patients.
Cureus
July 2024
Internal Medicine, Jackson Memorial Hospital, Miami, USA.
Article Synopsis
- Psoriasis is a chronic inflammatory skin condition that presents with distinct silvery plaques, commonly appearing on areas like the scalp, elbows, and knees, affecting both sexes equally.
- Two cases are presented where patients were misdiagnosed with tinea pedis (athlete's foot) but actually had psoriasis after failing to respond to standard antifungal treatments.
- The first patient improved with steroid cream, while the second, who was non-compliant with treatment, developed a serious infection (cellulitis) due to untreated psoriasis.
[Dermatomycoses: topical and systemic antifungal treatment].
Dermatologie (Heidelb)
August 2024
, Biebertal, Deutschland.
Article Synopsis
- * For conditions like pityriasis versicolor and severe dermatophytoses, treatments may involve oral medications, although many oral antifungals are off-label for kids in Germany; combining oral and topical therapies is recommended.
- * Terbinafine resistance is common in some dermatophyte infections, prompting the need for species identification and resistance testing; itraconazole is preferred for resistant cases, with alternative therapies like laser and photodynamic therapy also available.
CLARUS: An interactive explainable AI platform for manual counterfactuals in graph neural networks.
J Biomed Inform
February 2024
Institute for Medical Informatics, University Medicalcenter Göttingen, Germany.
Background: Lack of trust in artificial intelligence (AI) models in medicine is still the key blockage for the use of AI in clinical decision support systems (CDSS). Although AI models are already performing excellently in systems medicine, their black-box nature entails that patient-specific decisions are incomprehensible for the physician. Explainable AI (XAI) algorithms aim to "explain" to a human domain expert, which input features influenced a specific recommendation.
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