AI Article Synopsis
- Normal pressure hydrocephalus (NPH) can affect brain function and may be treatable with shunt surgery in about 60% of cases; imaging techniques like MRI are used to assess brain viability and oxygen use in these patients.
- Researchers analyzed 16 NPH patients by mapping oxygen extraction fraction (OEF) and cerebral blood flow (CBF) through specialized MRI methods, looking at the impact of various factors including age and brain volume.
- Findings showed that lower OEF was strongly linked to larger brain ventricular volumes, suggesting that as NPH severity increases, brain tissue oxygen usage decreases; this indicates that OEF mapping could help in tracking disease progression and treatment response.
Article Abstract
Objective: Normal pressure hydrocephalus (NPH) is a neurodegenerative disease that is potentially reversible by shunt surgery in approximately 60% of patients. Imaging may provide a means to investigate brain tissue viability and oxygen metabolism in NPH patients.
Methods: Oxygen extraction fraction (OEF) mapping was generated from 3D multi-echo gradient echo MRI (mGRE) data using QQ-CCTV algorithm and cerebral blood flow (CBF) using 3D arterial spin labeling (ASL) MRI data, thereby calculating the cerebral metabolic rate of oxygen (CMRO = CBF × OEF × [H]) in 16 NPH patients. Regression analyses using cortical gray matter and deep gray matter regions were conducted with age, gender, CSF stroke volume and normalized ventricular volume as independent variables.
Results: OEF showed significant negative correlations with normalized brain ventricular volumes in the whole brain (p = 0.004, q = 0.01), cortical gray matter (p = 0.004, q = 0.01), caudate (p = 0.02, q = 0.04), and pallidum (p = 0.03, q = 0.04), but no significant correlation with CSF stroke volume (q > 0.05). There was no significant finding with CBF or CMRO.
Conclusion: In NPH patients, low OEF in several regions was significantly correlated with large ventricular volumes, indicating decreased tissue oxygen metabolism with increased NPH severity. OEF mapping may provide a functional understanding of neurodegeneration in NPH and may improve monitoring of disease course and treatment outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081162 | PMC |
| http://dx.doi.org/10.1016/j.clinimag.2023.02.001 | DOI Listing |
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