In the present study, a novel and green temperature-responsive deep eutectic solvent (TRDES) system was developed and applied for the simultaneous extraction and separation of different polar active phytochemicals from Schisandra chinensis (Turcz.) Baill. The TRDES, consisting of amino alcohols and phenolic compounds, was chosen as the switching medium, and an upper critical solution temperature (UCST) type switchable solvent was obtained by adding an inorganic salt solution. The switchable phase diagram was plotted based on the relationship between the phase change temperature, the concentration and the amount of sodium chloride solution. Under optimal parameters, the yields with TRDES for different polar active phytochemicals (lignanoids and polysaccharides) from the dried fruit of Schisandra chinensis (DFSC) were 1.62 ∼ 1.17-fold and 1.39-fold to those with conventional solvents. Also, the TRDES system was still effective on extraction of DFSC lignanoids and polysaccharides after four cycles of extraction. The separated polysaccharides and lignanoids both had strong antioxidant activities with IC values of 1.92 mg/ mL and 0.10 mg/ mL against 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS), respectively. The extraction mechanism of TRDES was postulated by Density functional theory (DFT) calculations the hydrogen bonding in TRDES was the main factor to the higher extraction yield. This temperature-responsive deep eutectic solvent could be widely used for the efficient extraction and separation of multi-polar components. As a green and recyclable solvents, TRDES has great potential for the lower cost production from plants.
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http://dx.doi.org/10.1016/j.foodres.2023.112541 | DOI Listing |
J Therm Biol
December 2024
College of Environment and Resources, Dalian Minzu University, Dalian, 116600, China. Electronic address:
Thermal comfort is a subjective perception, hence conventional evaluation using meteorological factors faces a technical challenge in precise assessment. Human beings have the nature to differentiate expressions of facial emotions when varied thermal environments are perceived. Facial expression scores can be taken as a predictor of perceived thermal comfort which can be precisely assessed using deep learning against physical factors.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang, Jiangxi Province 330047, China. Electronic address:
Adv Healthc Mater
June 2024
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Hongshan Road, Nanjing, 210028, P. R. China.
Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age-related macular degeneration (wAMD). Here, a microemulsion-doped hydrogel (Bor/PT-M@TRG) is engineered as an intravitreal depot composing of temperature-responsive hydrogel (TRG) and borneol-decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)-coloaded microemulsions (Bor/PT-M). Bor/PT-M@TRG, functioning as the "ammunition depot", resides in the vitreous and continuously releases Bor/PT-M as the therapeutic "bullet", enabling deep penetration into the retina for 21 days.
View Article and Find Full Text PDFACS Appl Mater Interfaces
February 2024
Department of Biological Sciences and Bioengineering; Indian Institute of Technology Kanpur, Kanpur 208016, UP, India.
Impairment of intestinal epithelium is a typical feature of inflammatory bowel disease (IBD) that causes leakage of bacteria and antigens from the intestinal lumen and thus results in persistent immune activation. Hence, healing and regeneration of the damaged gut mucosa is a promising therapeutic approach to achieve deep remission in IBD. Currently, available systemic therapies have moderate effects and are often associated with numerous side effects and malignancies.
View Article and Find Full Text PDFLangmuir
May 2023
College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, P. R. China.
Hydrophobic deep eutectic solvents (HDESs) have been applied to colloidal systems such as microemulsions, despite the development of stimulus-responsive HDESs still being in a preliminary stage. Here, menthol and indole were hydrogen bonded to form CO-responsiveness HDES. A surfactant-free microemulsion constituted of HDES (menthol-indole) as the hydrophobic phase, water as the hydrophilic phase, and ethanol as the double solvent was demonstrated to be CO- and temperature-responsive.
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