The analysis of data on 208 cases of choriocarcinoma of different pathogenetic types established certain regularities of tumor dissemination into various organs. Metastases were observed in 33.3 +/- 5.1% of cases of choriocarcinoma of pathologic pregnancy. Dissemination was twice more frequent in patients suffering choriocarcinoma of normal (full-term or interrupted) pregnancy (56.2 +/- 4.5%; t = 3.4).

Download full-text PDF

Source

Publication Analysis

Top Keywords

cases choriocarcinoma
8
[metastatic spread
4
spread pathogenetic
4
pathogenetic variants
4
variants choriocarcinoma]
4
choriocarcinoma] analysis
4
analysis data
4
data 208
4
208 cases
4
choriocarcinoma pathogenetic
4

Similar Publications

Pulmonary artery choriocarcinoma mimicking pulmonary thromboembolism: a case report.

Transl Cancer Res

December 2024

Department of Geriatric Respiratory Disease, Institute of Guangdong Provincial Geriatrics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Background: Primary choriocarcinoma of the pulmonary artery is an exceedingly rare malignant neoplasm, which is often misdiagnosed due to its nonspecific clinical presentation. While this condition is characterized by the presence of trophoblastic cells, typically associated with gestational trophoblastic diseases, we encountered a case occurring in an extragenital location. The rarity of such tumors makes it challenging for clinicians to consider them in differential diagnosis, especially when the initial symptoms mimic more common conditions such as pulmonary thromboembolism (PTE).

View Article and Find Full Text PDF

A case of transient hyperthyroidism induced by placental site trophoblastic tumor.

J Obstet Gynaecol Res

January 2025

Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunkyō, Japan.

We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT.

View Article and Find Full Text PDF
Article Synopsis
  • Germ cell tumors (GCTs), particularly choriocarcinoma, show differing characteristics and treatment outcomes based on their location, with testicular choriocarcinoma being more common and showing better survival rates than nontesticular forms.
  • The study analyzed data from 363 patients diagnosed between 2000 and 2018, finding that 74.4% had testicular choriocarcinoma, with surgery being a common treatment for these patients, especially among white individuals.
  • The results suggest the importance of tailored treatment approaches for different choriocarcinoma subtypes, highlight racial disparities in incidence, and indicate that while surgery improves outcomes, the role of chemotherapy and radiotherapy in
View Article and Find Full Text PDF

Vaginal metastasis in gestational trophoblastic neoplasia: Experience from Sheffield trophoblastic disease Centre and recommendations for management.

Eur J Obstet Gynecol Reprod Biol

February 2025

Sheffield Trophoblastic Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Introduction: Gestational trophoblastic neoplasia (GTN) is rare in the UK, with an estimated incidence of one in 50,000 live births. Cases of vaginal metastasis are even rarer, with only eight case series reporting 187 cases over the past 40 years. Management recommendations in the literature are scarce despite the potential risk of massive, potentially life-threatening vaginal haemorrhage.

View Article and Find Full Text PDF

Human chorionic gonadotropin (hCG) has structural similarities with thyroid-stimulating hormone (TSH) and may stimulate TSH receptors at higher concentrations. During pregnancy, placental hCG causes TSH suppression, contributing to hyperemesis. However, in males, clinical manifestations caused by excess hCG are rare.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!