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COPD Airway Epithelial Cell-derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a.
Am J Respir Cell Mol Biol
January 2025
National Heart & Lung Institute, Imperial College London, Airway Disease Section, London, United Kingdom of Great Britain and Northern Ireland.
Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging, and the accumulation of senescent cells in lung tissue. MicroRNA (miR)-34a induces senescence by suppressing the anti-aging molecule, sirtuin-1 (SIRT1). Senescent cells spread senescence to neighbouring and distant cells, favouring COPD progression and its comorbidities.
View Article and Find Full Text PDFMenopause knowledge, attitudes and experiences of women in Saudi Arabia: a qualitative study.
BMC Womens Health
November 2024
UCL Research Department of Primary Care and Population Health, University College London, Upper 3rd Floor, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK.
Background: Menopause can be seen as a complex phenomenon influenced by an individual's cultural norms, belief systems, and lifestyle choices. In conservative societies such as Saudi Arabia, some women silently struggle with menopause due to cultural taboos and social stigma, making their experiences invisible and lowering their quality of life. The aim of this study was to explore in-depth the knowledge, attitudes, and experiences of middle-aged Saudi women with menopause.
View Article and Find Full Text PDFMicroalgae-bacteria consortia dynamics in a long term operated membrane-coupled high-rate algal pond (MHRAP).
J Environ Manage
December 2024
CALAGUA - Unidad Mixta UV-UPV, Departament d'Enginyeria Química, Universitat de València, Avinguda de la Universitat s/n, València, Burjassot, 46100, Spain. Electronic address:
Traditional activated sludge-based technologies have significant drawbacks, including high energy requirements and greenhouse gas emissions. Microalgae-based processes offer a promising, low-cost, and environmentally friendly alternative. However, the knowledge of treatment systems based on microalgae-bacteria consortia is limited, and even more so is their microbial composition and its relationship with operational parameters.
View Article and Find Full Text PDFEffect of the residual levofloxacin on hydroponic vegetables with sewage treatment plant tailwater: Microbial community, discharge risk and control strategy.
Ecotoxicol Environ Saf
October 2024
College of Life and Environmental Science, Wenzhou University, Wenzhou, Zhejiang 325035, PR China; State & Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou, Zhejiang 325035, PR China; Key Laboratory of Zhejiang Province for Water Environment and Marine Biological Resources Protection, Wenzhou, Zhejiang 325035, PR China. Electronic address:
Article Synopsis
- Tailwater-based hydroponics can recycle domestic wastewater but the impact of residual antibiotics like Levofloxacin (LVFX) on plant growth and water quality is not fully understood.
- Experiments showed that LVFX negatively affected water spinach growth, with the best removal of LVFX occurring after 7 days of water retention, while hydroponic conditions improved microbial diversity and stability.
- When testing lettuce with actual wastewater and LVFX, activated carbon was the most effective substrate, enhancing plant growth and achieving a high removal rate of LVFX and nitrogen compounds.
Injectable Biomimetic Hydrogel Constructs for Cell-Based Menopausal Hormone Therapy with Reduced Breast Cancer Potential.
Biomater Res
August 2024
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Hormone replacement therapy (HRT) has been a primary method in menopausal women and patients with ablated ovaries, but safety has been a concern. Cell-based HRT has emerged as an alternative approach without side effects causing pharmaceutical HRT via 3-dimensionally engineered constructs layering ovarian hormone-producing cells. In this study, we applied micro-sized ovarian cell-laden hydrogel beads as an approach to cell-based HRT using a minimally invasive method in the menopausal rat model.
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