AI Article Synopsis
- The kidneys are essential for regulating sodium balance in the body, using various sodium transporters throughout the nephron to manage different dietary intakes.
- Sodium reabsorption and urinary sodium excretion are closely tied to blood flow and filtration in the kidneys, which can lead to health issues like hypertension if disrupted.
- The article discusses updates in kidney sodium transport, including the influence of immune cells, lymphatics, interstitial sodium, and potassium as new regulators of this process.
Article Abstract
The kidneys play a critical role in maintaining total body sodium (Na) balance across a wide range of dietary intake, accomplished by a concerted effort involving multiple Na transporters along the nephron. Furthermore, nephron Na reabsorption and urinary Na excretion are closely linked to renal blood flow and glomerular filtration such that perturbations in either of them can modify Na transport along the nephron, ultimately resulting in hypertension and other Na-retentive states. In this article, we provide a brief physiological overview of nephron Na transport and illustrate clinical syndromes and therapeutic agents that affect Na transporter function. We highlight recent advances in kidney Na transport, particularly the role of immune cells, lymphatics, and interstitial Na in regulating Na reabsorption, the emergence of potassium (K) as a regulator of Na transport, and the evolution of the nephron to modulate Na transport.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1053/j.akdh.2022.12.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!