AI Article Synopsis
- * Challenges arise from the limited understanding of genetic testing among transplant practitioners, including issues with selecting tests, interpreting results, and providing proper counseling, often due to a lack of access to specialized genetic professionals.
- * While genetic testing shows potential benefits in donor evaluations, its effectiveness is not yet proven, and it can cause confusion, misclassification of donor eligibility, or false reassurance; thus, more data is needed for responsible implementation.
Article Abstract
The growing accessibility and falling costs of genetic sequencing techniques has expanded the utilization of genetic testing in clinical practice. For living kidney donation, genetic evaluation has been increasingly used to identify genetic kidney disease in potential candidates, especially in those of younger ages. However, genetic testing on asymptomatic living kidney donors remains fraught with many challenges and uncertainties. Not all transplant practitioners are aware of the limitations of genetic testing, are comfortable with selecting testing methods, comprehending test results, or providing counsel, and many do not have access to a renal genetic counselor or a clinical geneticist. Although genetic testing can be a valuable tool in living kidney donor evaluation, its overall benefit in donor evaluation has not been demonstrated and it can also lead to confusion, inappropriate donor exclusion, or misleading reassurance. Until more published data become available, this practice resource should provide guidance for centers and transplant practitioners on the responsible use of genetic testing in the evaluation of living kidney donor candidates.
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| http://dx.doi.org/10.1016/j.ajt.2023.02.020 | DOI Listing |
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