Antimicrobial and self-cleaning surface coatings are promising tools to combat the growing global threat of infectious diseases and related healthcare-associated infections (HAIs). Although many engineered TiO-based coating technologies are reporting antibacterial performance, the antiviral performance of these coatings has not been explored. Furthermore, previous studies have underscored the importance of the "transparency" of the coating for surfaces such as the touch screens of medical devices. Hence, in this study, we fabricated a variety of nanoscale TiO-based transparent thin films (anatase TiO, anatase/rutile mixed phase TiO, silver-anatase TiO composite, and carbon nanotube-anatase TiO composite) via dipping and airbrush spray coating technologies and evaluated their antiviral performance (Bacteriophage MS2 as the model) under dark and illuminated conditions. The thin films showed high surface coverage (ranging from 40 to 85%), low surface roughness (maximum average roughness 70 nm), super-hydrophilicity (water contact angle 6-38.4°), and high transparency (70-80% transmittance under visible light). Antiviral performance of the coatings revealed that silver-anatase TiO composite (nAg/nTiO) coated samples achieved the highest antiviral efficacy (5-6 log reduction) while the other TiO coated samples showed fair antiviral results (1.5-3.5 log reduction) after 90 min LED irradiation at 365 nm. Those findings indicate that TiO-based composite coatings are effective in creating antiviral high-touch surfaces with the potential to control infectious diseases and HAIs.
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http://dx.doi.org/10.1016/j.chemosphere.2023.138280 | DOI Listing |
Cancer Control
January 2025
Department of Pharmacy, Wuhan Third Hospital, Wuhan, China.
Objective: This study aimed to evaluate hepatitis B virus (HBV) reactivation and its effect on tumor response and survival outcomes in patients with HBV-related advanced hepatocellular carcinoma (HCC) undergoing lenvatinib plus camrelizumab treatment.
Methods: 216 patients with HBV-related advanced HCC receiving lenvatinib and camrelizumab were enrolled. Overall survival (OS), progression-free survival, and tumor response were evaluated.
Int J Biol Macromol
January 2025
Virus Research Laboratory, ICMR-National Institute of Cholera and Enteric Disease, Kolkata 700010, India. Electronic address:
Human cytomegalovirus (HCMV) is a common herpesvirus that can severely affect transplant recipients, those with AIDS, and newborns. Existing synthetic medications face limitations, including toxicity, processing issues, and viral resistance. As part of this study, the efficacy of the extracellular enzyme laccase isolated from a widely available mushroom (Pleurotus pulmonarius) was compared to that of ganciclovir, a common antiviral, used against HCMV.
View Article and Find Full Text PDFCatatonia is one of the most severe psychiatric syndromes, and clinical symptoms and etiology are very heterogeneous. When accompanied by autonomic instability and hyperthermia it’s termed malignant catatonia, which left untreated is associated with significant morbidity and mortality. First-line treatment is high dose benzodiazepines, followed by electroconvulsive therapy (ECT), in case of non-response.
View Article and Find Full Text PDFTunis Med
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, La Rabta Tertiary Hospital, Intensive Care Medicine Department, 1007, Tunis, Tunisia.
Unlabelled: Introduction Invasive candidiasis (IC) is a widespread infection in intensive care. As culture-based diagnostic techniques take several days before positivity and leaks of sensitivity. (1,3)-β-D-glucan (BDG) was proposed as a mycological criterion for IC diagnosis in selected patients.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Background: Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cancer acceleration, known as hyperprogressive disease (HPD), whose causative mechanisms are still unclear.
Methods: This study investigated the mechanisms of ICI resistance in an HPD-NSCLC model.
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