AI Article Synopsis
- Quinolizidomycins A and B are newly discovered quinolizidine alkaloids with a unique tricyclic ring structure, isolated from the *Streptomyces* species KIB-1714.
- Their chemical structures were determined through detailed spectroscopic analyses and X-ray diffraction techniques.
- Research indicates that these compounds are synthesized using lysine, ribose 5-phosphate, and acetate, suggesting a novel assembly process in their biosynthesis; Quinolizidomycin A has shown activity in inhibiting acetylcholinesterase.
Article Abstract
Quinolizidomycins A () and B (), two unprecedented quinolizidine alkaloids featuring a tricyclic 6/6/5 ring system, were isolated from sp. KIB-1714. Their structures were assigned by detailed spectroscopic data analyses and X-ray diffraction. Stable isotope labeling experiments suggested that compounds and are derived from lysine, ribose 5-phosphate, and acetate units, which indicates an unprecedented manner of assembly of the quinolizidine (1-azabicyclo[4.4.0]decane) scaffold in quinolizidomycin biosynthesis. Quinolizidomycin A () was active in an acetylcholinesterase inhibitory assay.
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| http://dx.doi.org/10.1021/acs.orglett.3c00478 | DOI Listing |
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