AI Article Synopsis
- The study compares video-assisted mediastinoscopy esophagectomy (VAME) and video-assisted thoracoscopy esophagectomy (VATE) for patients with esophageal cancer to evaluate their clinicopathological features and perioperative outcomes.
- Among the 733 patients analyzed, those undergoing VAME had more pulmonary comorbidities, but the procedure resulted in a significantly shorter operation time and fewer lymph nodes retrieved compared to VATE.
- Overall, VAME did not lead to an increase in complications or mortality despite the differences in operation time and lymph node retrieval, indicating it may be a safe option for patients with esophageal cancer.
Article Abstract
Objective: To compare the clinicopathological features and perioperative outcomes of video-assisted mediastinoscopy esophagectomy (VAME) compared to video-assisted thoracoscopy esophagectomy (VATE) in esophageal cancer.
Methods: We comprehensively searched online databases (PubMed, Embase, Web of Science and Wiley online library) to find available studies exploring the clinicopathological features and perioperative outcomes between VAME and VATE in esophageal cancer. Relative risk (RR) with 95% confidence interval (CI) and standardized mean difference (SMD) with 95% CI were used to evaluate the perioperative outcomes and clinicopathological features.
Results: A total of seven observational studies and one randomized controlled trial involving 733 patients were considered eligible for this meta-analysis, of which 350 patients underwent VAME in contrast to 383 patients underwent VATE. Patients in the VAME group had more pulmonary comorbidities (RR = 2.18, 95% CI 1.37-3.46, = 0.001). The pooled results showed that VAME shortened the operation time (SMD = -1.53, 95% CI -2.308--0.76, = 0.000), and retrieved less total lymph nodes (SMD = -0.70, 95% CI -0.90--0.50, = 0.000). No differences were observed in other clinicopathological features, postoperative complications or mortality.
Conclusions: This meta-analysis revealed that patients in the VAME group had more pulmonary disease before surgery. The VAME approach significantly shortened the operation time and retrieved less total lymph nodes and did not increase intra- or postoperative complications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971490 | PMC |
| http://dx.doi.org/10.3389/fsurg.2023.1039615 | DOI Listing |
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