ULTRASTRUCTURAL FEATURES OF THE REARRANGEMENT OF THE CELLS OF THE HEMATOTESTICULAR BARRIER AND THE SPERMATOGENIC EPITHELIUM OF THE RATS TESTICLES DURING THE SUDDEN WITHDRAWAL OF PREDNISOLONE AFTER ITS LONG-TERM INTRODUCTION IN HIGH DOSES.

With long-term use of hormonal drugs, according to the principle of "negative feedback", the production of own hormones by the endocrine glands is inhibited. With sudden withdrawal, in particular, of glucocorticoids, there are processes that threaten the development of secondary adrenal insufficiency. The purpose of the study: to establish the peculiarities of the reconstruction of the cellular elements of the testicles of white rats after the withdrawal of high doses of prednisolone. An ultrastructural study was performed on 60 male rats. It has been established that the sudden withdrawal of prednisolone after long-term introduction in high doses causes changes in the body that can be characterized as a state of "acute hypocorticism." At the same time, further progression of the dystrophic-destructive processes that occurred during the preliminary long-term introduction of the drug occurs. The most pronounced such changes were observed up to 7 days after cancellation. Then their intensity decreased, and by the 14th day signs of regenerative processes appeared, which gradually increased. Therefore, by the 28th day of the experiment, the ultrastructure of the cellular elements of the testicles was almost completely restored, which may be evidence of the high compensatory and regenerative ability of animals of this species, which must be taken into account when extrapolating the results to humans.