Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41574-023-00814-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design and maintenance of medical oxygen concentrators in Sub-Saharan Africa: a systematic review.
BMC Health Serv Res
January 2025
Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, 00128, Italy.
Background: Oxygen therapy is critical and vital treatment for hypoxemia and respiratory distress, however, access to reliable oxygen systems remains limited in SSA. Despite WHO initiatives that distributed over 30,000 OC oxygen concentrators worldwide, SSA faces significant challenges related to their maintenance and use, due to harsh environmental conditions, technical skill shortages and inadequate infrastructure. This review aims to systematically identify and assess the literature on OC design adaptations, maintenance challenges, and knowledge gaps in SSA, providing actionable recommendations to inform innovative and context-sensitive solutions to improve healthcare delivery in the region.
View Article and Find Full Text PDFMarigold: a machine learning-based web app for zebrafish pose tracking.
BMC Bioinformatics
January 2025
Biology Department, University of Massachusetts Amherst, Amherst, MA, USA.
Background: High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and larvae are ideal for such applications because they are spawned in large clutches, develop rapidly, feature a relatively simple nervous system, and have orthologs to many human disease genes. However, existing software for video-based behavioral analysis can be incompatible with recordings that contain dynamic backgrounds or foreign objects, lack support for multiwell formats, require expensive hardware, and/or demand considerable programming expertise.
View Article and Find Full Text PDFInferring the energy cost of resistance to parasitic infection and its link to a trade-off.
BMC Ecol Evol
January 2025
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
Background: In infected hosts, immune responses trigger a systemic energy reallocation away from energy storage and growth, to fuel a costly defense program. The exact energy costs of immune defense are however unknown in general. Life history theory predicts that such costs underpin trade-offs between host disease resistance and other fitness related traits, yet this has been seldom assessed.
View Article and Find Full Text PDFBrCYP71 mutation resulted in stay-green in pak choi (Brassica rapa L. ssp. chinensis).
Theor Appl Genet
January 2025
College of Horticulture, Shenyang Agricultural University, Shenyang, 110866, People's Republic of China.
BrCYP71 encoding multifunctional oxidase was mapped using BSA-Seq and linkage analysis, and its function in stay-green of pak choi was verified through Arabidopsis heterologous transgenic experiment. Stay-green refers to the phenomenon that plant leaves remain green during senescence and even after death, which is of great significance for improving the commerciality of leafy vegetables during storage or transportation and extending their shelf life. In this study, we identified a stay-green mutant of pak choi and named it nye2.
View Article and Find Full Text PDFAdapting a style based generative adversarial network to create images depicting cleft lip deformity.
Sci Rep
January 2025
Division of Plastic, Craniofacial and Hand Surgery, Sidra Medicine, and Weill Cornell Medical College, C1-121, Al Gharrafa St, Ar Rayyan, Doha, Qatar.
Training a machine learning system to evaluate any type of facial deformity is impeded by the scarcity of large datasets of high-quality, ethics board-approved patient images. We have built a deep learning-based cleft lip generator called CleftGAN designed to produce an almost unlimited number of high-fidelity facsimiles of cleft lip facial images with wide variation. A transfer learning protocol testing different versions of StyleGAN as the base model was undertaken.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!