Uncertainty associated with nuclear counting analyses are attributed to two main components of uncertainty; one is related to sampling, the other to sample preparation and the subsequent nuclear counting. The ISO/IEC 17025 standard of 2017 require accredited laboratories carrying out their own sampling to estimate the uncertainty associated with sampling in the field. This study presents the results of a sampling campaign and analysis by gamma spectrometry to determine the sampling uncertainty related to the measurement of radionuclides in soil.
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http://dx.doi.org/10.1016/j.apradiso.2023.110727 | DOI Listing |
PLoS Genet
January 2025
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Recent statistical approaches have shown that the set of all available genetic variants explains considerably more phenotypic variance of complex traits and diseases than the individual variants that are robustly associated with these phenotypes. However, rapidly increasing sample sizes constantly improve detection and prioritization of individual variants driving the associations between genomic regions and phenotypes. Therefore, it is useful to routinely estimate how much phenotypic variance the detected variants explain for each region by taking into account the correlation structure of variants and the uncertainty in their causal status.
View Article and Find Full Text PDFPLoS One
January 2025
Tranzo, Scientific Center for Care and Wellbeing, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.
Objective: An increasing number of people resumes life after cancer treatment. Although the (long-term) side-effects of cancer and its treatment can be significant, less is known about the impact on cancer survivors' participation in daily life. The aim of this study was to explore the common experiences of cancer survivors in resuming life after treatment.
View Article and Find Full Text PDFPLoS One
January 2025
Institute for Biomedical Ethics, University of Basel, Basel, Switzerland.
Introduction: 22q11 deletion syndrome (22q11DS) results from a microdeletion on chromosome 22 and is the most common microdeletion disorder in humans, affecting 1 in 2148 live births. Clinical manifestations vary widely among individuals and across different life stages. Effective management requires the involvement of a specialized multidisciplinary team.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
ARC Training Centre in Cognitive Computing for Medical Technologies, Parkville, VIC, Australia.
Background: The modelling of biomarker dynamics in Alzheimer's Disease from cohort studies faces challenges due to the lack of clear temporal points of references and the natural variability across individuals. Mixed-effects models are often used to account for individual differences, but a disease timescale can enable better population-level modelling than age or time since enrolment. Previous literature explored the temporal synchronisation of patients through observed time of conversion to MCI or AD, amyloid positivity, or aligning cognitive trajectories.
View Article and Find Full Text PDFBackground: Disease-modifying therapies (DMTs) such as lecanemab and aducanumab are recommended for the treatment of patients with confirmed Alzheimer's disease (AD) within the mild cognitive impairment (MCI) or mild stages of dementia. Biomarker testing is required to confirm the presence of amyloid beta for prescription of DMTs. Confirmatory diagnosis at the MCI stage is important to take advantage of the narrow treatment window of currently available DMTs.
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