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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma.
BMC Cancer
January 2025
Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, People's Republic of China.
Background: Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide. Various factors in the tumor environment (TME) can lead to the activation of endoplasmic reticulum stress (ERS), thereby affecting the occurrence and development of tumors. The objective of our study was to develop and validate a radiogenomic signature based on ERS to predict prognosis and systemic combination therapy response.
View Article and Find Full Text PDFAn application of matching algorithms to generalize small-area estimates of chronic pain prevalence to neighbourhoods across England.
J Public Health (Oxf)
January 2025
Centre for Applied Health & Social Care Research (CARe), Robert Winston Building, Broomhall Road, Sheffield Hallam University, Sheffield S10 2BP, UK.
Background: Local decision-makers lack granular data on the prevalence of chronic pain in their populations. We applied matching methods to generalize estimates from one local survey in England to other neighborhoods across the country with a similar sociodemographic composition.
Methods: We used propensity score matching to match lower-layer super output areas (LSOA) across England with 230 surveyed LSOAs in North Staffordshire by age, sex, ethnicity, deprivation, and rurality.
Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury.
J Med Chem
January 2025
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong 510260, China.
Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) is a promising anti-inflammatory target for the treatment of respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series of benzimidazole derivatives as PDE4 inhibitors.
View Article and Find Full Text PDFA Road Map to the State of the Art of Magnesium Research - Highlights from the XVII International Magnesium Symposium, Grottaferrata 5-6 September 2024.
Magnes Res
January 2025
Department of Biomedical and Clinical Sciences, Università di Milano, Via GB Grassi 74 - 20157 Milano, Italy.
Intact N-glycopeptide analysis of human platelets reveals a Glycostructure important for platelet function.
Glycobiology
January 2025
Institute of Blood Transfusion, Shanghai Blood Center, 1191 Hongqiao Road, Shanghai 200051, China.
Glycosylation is an important posttranslational modification in platelets, and the glycosylation pattern is critical for platelet function. To date, the exploration of the roles of various glycoforms in specific platelet functions is largely lacking. In this study, a global analysis of intact N-glycopeptides in human platelets was performed to map all the glycopeptides, glycosites and glycans of platelets.
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