AI Article Synopsis
- Traditional treatments for chronic diabetic ulcers struggle due to complications from microangiopathy and infections, prompting interest in alternative solutions.
- Recent advances have highlighted the use of composite hydrogels, which can be enhanced with various components to improve their effectiveness in healing these wounds.
- This review presents a range of currently utilized and potential new loading components for hydrogels, including different biological and chemical agents, aimed at aiding researchers in developing more effective treatments for chronic diabetic ulcers.
Article Abstract
Due to recalcitrant microangiopathy and chronic infection, traditional treatments do not easily produce satisfactory results for chronic diabetic ulcers. In recent years, due to the advantages of high biocompatibility and modifiability, an increasing number of hydrogel materials have been applied to the treatment of chronic wounds in diabetic patients. Research on composite hydrogels has received increasing attention since loading different components can greatly increase the ability of composite hydrogels to treat chronic diabetic wounds. This review summarizes and details a variety of newly loaded components currently used in hydrogel composites for the treatment of chronic diabetic ulcers, such as polymer/polysaccharides/organic chemicals, stem cells/exosomes/progenitor cells, chelating agents/metal ions, plant extracts, proteins (cytokines/peptides/enzymes) and nucleoside products, and medicines/drugs, to help researchers understand the characteristics of these components in the treatment of diabetic chronic wounds. This review also discusses a number of components that have not yet been applied but have the potential to be loaded into hydrogels, all of which play roles in the biomedical field and may become important loading components in the future. This review provides a "loading component shelf" for researchers of composite hydrogels and a theoretical basis for the future construction of "all-in-one" hydrogels.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968980 | PMC |
| http://dx.doi.org/10.3389/fbioe.2023.1077490 | DOI Listing |
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