N6-methyladenosine (mA) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by mA writers, erasers, and readers, mA modulation is involved in myriad physiological and pathological processes. Extensive studies have demonstrated mA modulation in diverse tumours, with effects on tumorigenesis, metastasis, and resistance. Recent evidence has revealed an emerging role of mA modulation in tumour immunoregulation, and divergent mA methylation patterns have been revealed in the tumour microenvironment. To depict the regulatory role of mA methylation in the tumour immune microenvironment (TIME) and its effect on immune evasion, this review focuses on the TIME, which is characterized by hypoxia, metabolic reprogramming, acidity, and immunosuppression, and outlines the mA-regulated TIME and immune evasion under divergent stimuli. Furthermore, mA modulation patterns in anti-tumour immune cells are summarized.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976403 | PMC |
| http://dx.doi.org/10.1186/s12943-022-01704-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
spp., and Threats to the Food Industry and Public Health.
Foodborne Pathog Dis
January 2025
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
Foodborne pathogens have always been of public health concern and represent safety issues for food processors. These pathogens develop new ways to overcome antibiotics, survive in different environmental conditions, and the ability to reproduce in many hostile environments configure them as serious health hazards. Considering the huge number of microorganisms, three bacterial representatives were selected to provide a better knowledge about the question of which one is the worst enemy for humans, from the food industry point of view, taking into consideration their multiplication specificity, virulence, and resistance.
View Article and Find Full Text PDFModeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis.
Hum Cell
January 2025
Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore, India.
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with oral squamous cell carcinoma (OSCC), highlighting the importance of understanding tumor-node cross-talk for effective prognostic and therapeutic interventions. Herein, we describe the development and characterization of primary lymph node stromal cells (LNSCs, N = 14) from nodes of metastatic and non-metastatic OSCC patients. Primary cultures were established by the explant method from positive (N + ; N = 2), and negative nodes (N0; N = 4) of the metastatic patients (N = 3) as well as negative (N0; N = 8) nodes from non-metastatic (N = 4) patients.
View Article and Find Full Text PDFBetacoronavirus internal protein: role in immune evasion and viral pathogenesis.
J Virol
January 2025
Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Betacoronaviruses express a small internal (I) protein that is encoded by the same subgenomic RNA (sgRNA) as the nucleocapsid (N) protein. Translation of the +1 reading frame of the N sgRNA through leaky ribosomal scanning leads to expression of the I protein. The I protein is an accessory protein reported to evade host innate immune responses during coronavirus infection.
View Article and Find Full Text PDFTumor β-Catenin Expression Associated With Poor Prognosis to Anti-PD-1 Antibody Monotherapy in Non-small Cell Lung Cancer.
Cancer Diagn Progn
January 2025
Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
Background/aim: Tumor intrinsic β-catenin signaling has been reported to influence the tumor immune microenvironment and may be a resistance mechanism to immune checkpoint inhibitors in various cancers.
Patients And Methods: We studied the association between tumor β-catenin expression and survival in 50 patients with non-small cell lung cancer (NSCLC) treated with anti-programmed death-1 antibody monotherapy. Tumor β-catenin expression was evaluated by immunohistochemistry.
Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV.
Natl Sci Rev
January 2025
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
The Mpox virus (MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes (G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!