Prevalence of orofacial alterations in patients with sickle-cell disease: Systematic review and meta-analysis.

Themis Macedo Pereira da Costa Monikelly do Carmo Chagas Nascimento Mariela Peralta-Mamani Izabel Regina Fischer Rubira-Bullen José Luiz Cintra Junqueira Mariana Quirino Silveira Soares

Oral Surg Oral Med Oral Pathol Oral Radiol

Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil. Electronic address:

Published: May 2023

The study aimed to find out how common orofacial changes are in people with sickle-cell disease (SCD) and to compare these findings with those from the general population.
A total of 28 studies were selected from 770 records, indicating significant issues like decreased bone density (57%), malocclusion (66%), and delayed tooth eruption (20%) in SCD patients.
The research noted a high risk of bias due to small sample sizes and a lack of comparisons between SCD patients and healthy individuals regarding these orofacial alterations.

Objective: The aim of this study was to identify the prevalence of orofacial alterations in sickle-cell disease (SCD) and to compare it with the general population.

Study Design: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The search was conducted on PubMed, Embase, Scientific Electronic Library Online, Web of Science, Cochrane Library, gray literature, and references of the included articles.

Results: A total of 770 records were found, and 28 studies were selected. In SCD, the prevalence of decreased bone density was 57% (95% CI: 35%-80%), with Q: P < .01 and I = 95%; for stepladder pattern was 30% (IC: 13%-47%), Q: P < .01 and I²: 93%; for delayed eruption was 20% (95% CI: 6%-34%), with Q: P < .01 and I = 86, Q: P < .01 and I = 99%; and for malocclusion, 66% (95% CI: 39%-92%), Q: P < .01 and I = 98%. A high risk of bias was observed in relation to the sample size of the studies. A limited number of articles compared the prevalence of orofacial alterations in patients with SCD and healthy individuals.

Conclusions: Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay, periodontal disease, and neuropathies may be present in patients with SCD with variable prevalence.

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.oooo.2022.12.009	DOI Listing

Publication Analysis

Top Keywords

prevalence orofacial

orofacial alterations

alterations patients

sickle-cell disease

decreased bone

bone density

patients scd

prevalence

patients sickle-cell

disease systematic

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!