Purine Content and Renal Acid Load Evaluation in Healthy Japanese Diets.

J Nutr Sci Vitaminol (Tokyo)

Laboratory of Clinical Nutrition and Management, Graduate Division of Nutritional and Environmental Sciences, and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, The University of Shizuoka.

Published: March 2023

AI Article Synopsis

  • Attention to purine intake is crucial for managing hyperuricemia, particularly in patients who are also obese and seek to lose weight through glucose restriction.
  • A study compared the purine content and potential renal acid load (PRAL) of normal hospital diets, energy-control diets, and low-carbohydrate diets, finding that low-carb diets had significantly higher purine content.
  • It is advised that dietitians prefer hospital diets over low-carb diets for patients with hyperuricemia due to lower purine intake and acid load in the former.

Article Abstract

During the treatment of hyperuricemia, attention should be paid to purine intake as part of the diet. Additionally, many patients with obese hyperuricemic expect early weight loss through glucose restriction. However, the amounts of purine in the diet are unknown. This study aimed to compare the purine content and potential renal acid load (PRAL) of a hospital diet and a low carbohydrate (LC). We calculated the nutritional values in the menus of the normal hospital (NH), energy-control (EC) diets served at several Shizuoka general hospitals, and the menus of LC diets. The amount of purine and PRAL was determined based on the nutritional values. The average daily purine content and energy were NH 349.0 mg, 1,808 kcal, EC 340.4 mg, 1,681 kcal, and LC 697.6 mg, 1,454 kcal, respectively. LC consumed more purine than the recommended daily intake of 400 mg. The PRAL score for NH was 4.5 mEq/d, EC 3.8 mEq/d, and LC 19.0 mEq/d, with LC representing diets with a higher acid load. In terms of both purine intake and uric acid excretion, the hospital diet is preferred over the low-carbohydrate diet for patients. Dietitians should exercise caution when recommending a low-carbohydrate diet for patients with hyperuricemia.

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http://dx.doi.org/10.3177/jnsv.69.7DOI Listing

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