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Bis-3-chloropiperidines: a novel motif for anthelmintic drug design.
RSC Adv
January 2025
Institute of Organic Chemistry, Justus Liebig University 35392 Giessen Germany https://www.uni-giessen.de/de/fbz/fb08/Inst/organische-chemie/AGGoettlich.
Parasites account for huge economic losses by infecting agriculturally important plants and animals. Furthermore, morbidity and death caused by parasites affect a large part of the world population, especially in economically weak regions. Anthelmintic drugs to tackle this challenge remain scarce and their efficiency becomes increasingly endangered by the advent of drug resistance development.
View Article and Find Full Text PDFDental Antimicrobial Stewardship: Developing a Mobile Application for Rational Antibiotic Prescribing to Tackle Misdiagnosis.
Antibiotics (Basel)
November 2024
Department of Restorative Odontology and Endodontics, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Background/objectives: Inexperienced dentists and dental students are especially prone to misdiagnosis, and this represents a huge problem regarding antimicrobial stewardship. We aimed to develop a mobile app for rational antibiotic prescribing in dentistry based on local-systemic symptoms and patient factors, rather than solely on diagnosis, to tackle misdiagnosis.
Methods: The study involved 64 participants, 50 of which were third-year dental students attending a pharmacology course focusing on antimicrobials, comprising lectures and practical sessions without (noAPP group, n = 22) or with (APP group n = 28) the assistance of a mobile application.
Linear Mixed Modeling of Federated Data When Only the Mean, Covariance, and Sample Size Are Available.
Stat Med
January 2025
Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BioStat), Data Science Institute (DSI), Hasselt University, Hasselt, Belgium.
In medical research, individual-level patient data provide invaluable information, but the patients' right to confidentiality remains of utmost priority. This poses a huge challenge when estimating statistical models such as a linear mixed model, which is an extension of linear regression models that can account for potential heterogeneity whenever data come from different data providers. Federated learning tackles this hurdle by estimating parameters without retrieving individual-level data.
View Article and Find Full Text PDFAquaculture requires special consideration in National Action Plans for Antimicrobial Resistance.
Sci Total Environ
January 2025
Institute of Aquaculture, University of Stirling, United Kingdom. Electronic address:
Article Synopsis
- * Aquaculture is an important yet underrepresented sector in NAPs, using significant antibiotics compared to human and terrestrial animal applications, and it requires tailored strategies due to its complexity and global trade implications.
- * To enhance NAPs for aquaculture, it’s crucial to recognize its diversity and engage stakeholders across the value chain, including health services, while ensuring policies consider the interconnectedness of human, animal, and environmental health.
A state-of-the-art review on the quantitative and qualitative assessment of water resources using google earth engine.
Environ Monit Assess
November 2024
Department of Hydrology, Indian Institute of Technology Roorkee, Roorkee, India.
Water resource management is becoming essential due to many anthropogenic and climatic factors resulting in dwindling water resources. Traditionally, geographic information systems (GIS) and remote sensing (RS) have long been instrumental in water resource assessment and management as the satellites or airborne units are periodically utilized to collect data from large areal extent. However, these platforms have limited computational capability and localized storage systems.
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