Although humans gain considerable knowledge from young to older adulthood, aging is also associated with cognitive deficits. This study investigated age-related changes in dynamic cognitive control adjustments after cognitive conflicts and errors. Specifically, we compared younger and older adults' time courses of two established phenomena - post-conflict slowing and post-error slowing. Both age groups completed modified versions of three widely used cognitive conflict tasks (Stroop, Simon, and flanker task). In these tasks, occasional incongruent information triggered a conflict that had to be resolved accordingly but sometimes elicited errors. We tracked conflict- and error-related slowing across four trials after a correct conflict trial (i.e., post-conflict slowing) and an incorrect conflict trial (i.e., post-error slowing). Post-error slowing was generally stronger than post-conflict slowing. Older adults showed a disproportionally strong slowing on the first post-error trial compared to younger adults. In contrast, on subsequent trials, older adults showed a relatively stronger speed up. This pattern of results was consistent across all three tasks. The greater cross-trial response time changes in older adults suggests a deficit in fine-tuning cognitive control adjustments.
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http://dx.doi.org/10.1016/j.actpsy.2023.103874 | DOI Listing |
CNS Neurosci Ther
January 2025
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Objectives: Parkinson's disease (PD) is characterized by olfactory dysfunction (OD) and cognitive deficits at its early stages, yet the link between OD and cognitive deficits is also not well-understood. This study aims to examine the changes in the olfactory network associated with OD and their relationship with cognitive function in de novo PD patients.
Methods: A total of 116 drug-naïve PD patients and 51 healthy controls (HCs) were recruited for this study.
The origins of resting-state functional MRI (rsfMRI) signal fluctuations remain debated. Recent evidence shows coupling between global cortical rsfMRI signals and cerebrospinal fluid inflow in the fourth ventricle, increasing during sleep and decreasing with Alzheimer's disease (AD) progression, potentially reflecting brain clearance mechanisms. However, the existence of more complex brain-ventricle coupling modes and their relationship to cognitive decline remains unexplored.
View Article and Find Full Text PDFThe biological mechanisms underlying women's increased Alzheimer's disease (AD) prevalence remain undefined. Previous case/control studies have identified sex-biased molecular pathways, but sex-specific relationships between gene expression and AD endophenotypes, particularly sex chromosomes, are underexplored. With bulk transcriptomic data across 3 brain regions from 767 decedents, we investigated sex-specific associations between gene expression and post-mortem β-amyloid and tau as well as antemortem longitudinal cognition.
View Article and Find Full Text PDFComput Struct Biotechnol J
December 2024
The State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory of Remote Measurement and Control, School of Instrument Science and Engineering, Southeast University, Nanjing 210096, China.
Object handover is a fundamental task for collaborative robots, particularly service robots. In in-home assistance scenarios, individuals often face constraints due to their posture and declining physical functions, necessitating high demands on robots for flexible real-time control and intuitive interactions. During robot-to-human handovers, individuals are limited to making perceptual judgements based on the appearance of the object and the consistent behaviour of the robot.
View Article and Find Full Text PDFCan one shift attention among voices at a cocktail party during a silent pause? Researchers have required participants to attend to one of two simultaneous voices - cued by its gender or location. Switching the target gender or location has resulted in a performance 'switch cost' - which was recently shown to reduce with preparation when a gender cue was presented in advance. The current study asks if preparation for a switch is also effective when a voice is selected by location.
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