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Reply to A. Abner et al.
J Clin Oncol
May 2023
Ting Martin, MA, Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA; Yilun Sun, PhD, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH; Daniel E. Spratt, MD, Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland Medical Center, Cleveland, OH; and Amar U. Kishan, MD, Departments of Radiation Oncology and Urology, University of California, Los Angeles, Los Angeles, CA.
The relation between the presence and extent of lobular carcinoma in situ and the risk of local recurrence for patients with infiltrating carcinoma of the breast treated with conservative surgery and radiation therapy.
Cancer
March 2000
Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02215, USA.
Background: When found in an otherwise benign biopsy, lobular carcinoma in situ (LCIS) has been associated with an increased risk of development of a subsequent invasive breast carcinoma. However, the association between LCIS and the risk of subsequent local recurrence in patients with infiltrating carcinoma treated with conservative surgery and radiation therapy has received relatively little attention.
Methods: Between 1968 and 1986, 1625 patients with clinical Stage I-II invasive breast carcinoma were treated at the Joint Center for Radiation Therapy at Harvard Medical School with breast-conserving surgery (CS) and radiation therapy (RT) to a total dose to the primary site of > or =60 grays.
Despite limited data, coexistent lobular carcinoma in situ should not be a contraindication to breast conservation for women with invasive breast carcinoma: reply.
Cancer
March 2000
Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts.
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