We report an efficient deep-UV master-oscillator power amplifier (MOPA) laser system at 229 nm that generates 350 ps pulses at 2 MHz repetition rate with an average power of 1.2 W. The use of a polarization-maintaining large mode area neodymium-doped fiber operating on the F→I transition allows high-power laser emission of up to 28 W near 915 nm in the sub-nanosecond regime with low spectral broadening. Two nonlinear frequency conversion stages (LBO + BBO crystals) in a single-pass configuration directly convert the IR laser emission to deep UV. This laser demonstrates the great potential of Nd-doped fiber lasers to produce high-power deep-UV emission.
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http://dx.doi.org/10.1364/OL.483718 | DOI Listing |
Nat Commun
January 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.
The development of mechanically robust super-lubrication hydrogel materials with sustained lubricity at high contact pressures is challenging. In this work, inspired by the durable lubricity feature of the earthworm epidermis, a multilevel structural super-lubrication hydrogel (MS-SLH) system, the so-called lubricant self-pumping hydrogel, is developed. The MS-SLH system is manufactured by chemically dissociating a double network hydrogel to generate robust and wrinkled lubrication layer, and then laser etching was used to generate cylindrical texture pores as gland-like pockets for storing lubricants.
View Article and Find Full Text PDFInt J Pharm
January 2025
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, PR China. Electronic address:
Traditional wound care preparations frequently face challenges such as complex care protocols, poor patient compliance, limited skin permeability, lack of aesthetics, and inconvenience, in addition to the risk of bacterial infection. We developed a spray film preparation containing nanocellulose and L-serine modified nanosilver, capable of rapidly forming a transparent film on the skin within minutes of application. The incorporation of nanocellulose imparted protective, moisturizing, and breathable properties to the film, allowing for easy removal after use.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Pharmacy School, Jinzhou Medical University, Jinzhou, China; Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, China; Key Laboratory of Medical Tissue Engineering of Liaoning Province, Jinzhou Medical University, Jinzhou, China. Electronic address:
In this study, we developed calcium alginate-coated nanovesicles derived from macrophage membranes loaded with berberine (Ber@MVs-CA) for the oral treatment of ulcerative colitis (UC). Ber@MVs-CA demonstrates resistance to gastric acid and controlled drug release in the colonic pH environment, while actively targeting sites of ulcerative colitis injury. pH-responsive release of Ber in Ber@MVs-CA was confirmed through in vitro release experiments.
View Article and Find Full Text PDFForensic Sci Int
December 2024
Ballistics Section of the Spanish Scientific Police Headquarters (National Police), Julián González Segador s/n, Madrid, Spain; Instituto Universitario de Investigación en Ciencias Policiales (IUICP), Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Firearm-related scenarios can be highly complex, involving multiple shooters, firearms, types of ammunition, victims, and various impact zones. Obtaining the maximum amount of information to connect each piece of the puzzle is crucial for resolving these cases. Currently, new tools are being developed in the forensic field that facilitate both fieldwork and laboratory analysis, enabling the estimation of trajectories, identification of shooters, and more.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, No.1 East Jianshe Road, Erqi District, Zhengzhou, 450052, China.
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement activation in DKD is of particular interest. In this study, the glomerular proteome, especially the profiles of the complement proteins, was analyzed in kidney biopsies from 40 DKD patients and 10 normal controls using laser microdissection-assisted liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS).
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