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http://dx.doi.org/10.1684/ejd.2022.4362DOI Listing

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Article Synopsis
  • The study focuses on vulvar acantholytic dyskeratoses, which are rare skin conditions affecting the vulva and perineum, with a goal to improve classification and understanding for gynecologic pathologists.
  • Between 1990 and 2023, 16 cases of vulvar acantholytic dyskeratoses were analyzed, mostly affecting women aged 36 to 79, with many presenting asymptomatic or pruritic lesions predominantly on the labia majora.
  • Histologically, these conditions showed features like acantholysis, with some patients responding to local excision or corticosteroids; however, no clear distinction was found between sporadic and syndromic cases based on
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Article Synopsis
  • A 70-year-old woman had a single wart-like growth on her leg and painful sores in her mouth.
  • Doctors considered possible conditions like lichen simplex chronicus and chromoblastomycosis before diagnosing her with pemphigus vegetans (PVeg).
  • This case emphasizes the need to include PVeg in diagnoses for unusual skin growths, even when they appear in unexpected areas of the body.
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Pemphigus vegetans is a rare type of pemphigus characterized by vegetative lesions primarily localized to the intertriginous area. Despite its unique clinical presentation, the underlying pathomechanism remains unclear owing to the rarity of the disease. We report a case of pemphigus vegetans with antibodies against desmoglein 1 and desmocollins 1-3.

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