AI Article Synopsis
- Cardiovascular disease (CVD) is linked to an increased risk of developing dementia, and the study aimed to explore how CVD events affect cognitive functioning over time.
- In a study of over 19,000 adults aged 65 and older, those who experienced a CVD event showed a short-term decline in processing speed, but no significant long-term effects were found on this metric.
- However, participants with CVD experienced faster declines in overall cognitive function, episodic memory, and verbal fluency, suggesting the need for ongoing cognitive monitoring after a CVD event.
Article Abstract
Introduction: Cardiovascular disease (CVD) is a recognized risk factor for dementia. Here we determined the extent to which an incident CVD event modifies the trajectory of cognitive function and risk of dementia.
Methods: 19,114 adults (65+) without CVD or dementia were followed prospectively over 9 years. Incident CVD (fatal coronary heart disease, nonfatal myocardial infarction [MI], stroke, hospitalization for heart failure) and dementia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) were adjudicated by experts.
Results: Nine hundred twenty-two participants had incident CVD, and 44 developed dementia after CVD (4.9% vs. 4.4% for participants without CVD). Following a CVD event there was a short-term drop in processing speed (-1.97, 95% confidence interval [CI]: -2.57 to -1.41), but there was no significant association with longer-term processing speed. In contrast, faster declines in trajectories of global function (-0.56, 95% CI: -0.76 to -0.36), episodic memory (-0.10, 95% CI: -0.16 to -0.04), and verbal fluency (-0.19, 95% CI: -0.30 to -0.01) were observed.
Discussion: Findings highlight the importance of monitoring cognition after a CVD event.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440246 | PMC |
| http://dx.doi.org/10.1002/alz.13006 | DOI Listing |
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