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Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group.
Hum Brain Mapp
January 2025
Amsterdam UMC, Department of Radiology and Nuclear Medicine, University of Amsterdam, Amsterdam, the Netherlands.
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that predict individual-level pharmacotherapeutic treatment response using cortical morphometry from multisite longitudinal cohorts. We conducted an international analysis of pooled data from six sites of the ENIGMA-MDD consortium (n = 262 MDD patients; age = 36.
View Article and Find Full Text PDFPatient-reported data on the severity of Von Willebrand disease.
Haemophilia
November 2024
Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Article Synopsis
- The study investigates how patients with Von Willebrand disease (VWD) perceive the severity of their condition, highlighting a gap in understanding patient experiences alongside traditional lab measures.
- A nationwide survey in the Netherlands included 736 VWD patients, who reported their disease severity, bleeding scores, and quality of life through a questionnaire.
- Results show that self-reported severity aligns well with clinical classifications, and factors like type of VWD, bleeding severity, gender, treatment history, and specific lab values significantly influence patients' perception of their disease severity.
The battle against the global fertility crisis: have we crossed the Rubicon?
Women Health
August 2024
Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Mesenteric Ischemia after Cardiac Surgery.
Thorac Cardiovasc Surg
October 2024
Department of Cardiac Surgery, University Heart Center Dresden, Medical Faculty Carl Gustav Carus of the Technical University of Dresden, Technische Universität Dresden, Dresden, Sachsen, Germany.
Article Synopsis
- Mesenteric ischemia (Me-Is) is a serious but underreported complication after cardiac surgery, affecting 0.47% of patients in a large study, with only 49.1% surviving after 30 days post-operation.
- The study found that most affected patients were older males, with many undergoing complex surgeries; both survivors and nonsurvivors showed no significant differences in clinical characteristics but differed in diagnosis methods.
- Key predictors of mortality included high norepinephrine doses and lactate levels, indicating that the prognosis for Me-Is is generally poor despite treatment interventions.
Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents.
Bioconjug Chem
January 2024
Department of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.
The Sulfo-NHS ester is a mainstay reagent for facilitating amide bond formation between carboxylic acids and amine functionalities in water. However, the preparation of Sulfo-NHS esters currently requires hydrophobic carboxylic acids, which are poorly water-soluble, to first be reacted with the -hydroxysulfosuccinimide sodium salt, which is insoluble in organic solvents. The mutually incompatible solvation requirements thus complicate the synthesis of Sulfo-NHS esters.
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