Background And Aim: is an intestinal protozoan in humans and animals. The parasite causes mild-to-severe intestinal complications, such as diarrhea, in healthy humans and immunocompromised hosts. This study aimed to determine the antiprotozoal activity of (L.) Mansf and (Fr.) Kart extracts against .
Materials And Methods: Antiprotozoal activity of and extracts against subtype 3 was determined using the erythrosin B exclusion assay, confirmed by a time-kill study. The morphology of the parasite treated with the extracts was observed by a scanning electron microscope. The phytochemicals present in and extracts were identified by gas chromatography-mass spectrometry analysis.
Results: Both and extracts demonstrated strong antiprotozoal activity with similar minimum inhibitory concentration (MIC) values of 62.5 μg/mL. At 4× MIC and 8× MIC, both and extracts, and metronidazole inhibited the growth of by up to 90% after 12 h treatment. cells treated with extract, extract, and metronidazole were deformed and withered when compared with the control. Geraniol and versalide were found as the main compounds in and extracts, respectively.
Conclusion: These results indicate the potential medicinal benefits of and extracts in the growth inhibition of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967722 | PMC |
| http://dx.doi.org/10.14202/vetworld.2023.187-193 | DOI Listing |
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