New Azacycles by One-Pot Three-Component Hantzsch-Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4-b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes (H. Butenschön, I. A. Abdelhamid et al.) #OpenAccess Multicomponent reactions (MCRs) are envisaged as an entry point for the synthesis of heterocyclic compounds with interesting biological activities. An efficient approach to annelated tetra(hexa)azacyclopenta[a]anthracenes, tetraazaindeno[5,4-b]fluorenes, and oxatetraazacyclopenta[m]tetraphene was accomplished using a three-component reaction involving 7-amino-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-5-one with aromatic aldehydes and the corresponding active 1,3-dicarbonyl compounds (namely, dimedone, 1,3-dimethylbarbituric acid, 1,3-indanedione, and 4-hydroxycoumarine). The reactions were conducted in glacial acetic acid at reflux for 5 h to give the desired products in good yields (62-83 %). The chemical constitutions of all new products were confirmed spectroscopically.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975464PMC
http://dx.doi.org/10.1002/open.202300009DOI Listing

Publication Analysis

Top Keywords

tetrahexaazacyclopenta[a]anthracenes tetraazaindeno[54-b]fluorenes
12
azacycles one-pot
8
one-pot three-component
8
three-component hantzsch-like
8
hantzsch-like synthesis
8
synthesis tetrahexaazacyclopenta[a]anthracenes
8
tetraazaindeno[54-b]fluorenes oxatetraazacyclopenta[m]tetraphenes
8
oxatetraazacyclopenta[m]tetraphenes azacycles
4
oxatetraazacyclopenta[m]tetraphenes butenschön
4
butenschön abdelhamid
4

Similar Publications

New Azacycles by One-Pot Three-Component Hantzsch-Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4-b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes (H. Butenschön, I. A.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!