Quaternary Ammonium Salt Strategy and Molecular Docking Studies of Novel 5-Acyl-8-(Arylamino)-Quinolines by Acetyl and Methanesulfonyl Chloride for Dual Evaluation Bioactivity.

Unlabelled: Six quinoline derivatives containing quaternary ammonium salts and acyl chloride groups were synthesized from ethyl 8-chloro-[1,3]dioxolo[4,5-]quinoline-7-carboxylate in several step. With berberine as the positive control, three human cancer cell lines (HCT-116, Hela and A549) and human normal liver L-02 cell lines were used to evaluate the cytotoxicity of the newly synthesized compounds in vitro. Compound (-) showed good antitumor activity, and the test result of compound () was better than that of positive control group. In terms of antibacterial activity, compound (-) has obvious inhibitory effect on (ATCC 29213) and (ATCC 8739), and its antibacterial activity is about 1-4 times that of positive control amoxicillin and 1-2 times that of ciprofloxacin. Among them, the most effective compounds () and () have 4-fold the antibacterial activity of amoxicillin and 2-fold the antibacterial activity of ciprofloxacin.

Supplementary Information: The online version contains supplementary material available at 10.1134/S1068162023020097.