AI Article Synopsis
- Glecaprevir/pibrentasvir (GP) is a first-line treatment for hepatitis C, but it can cause serious liver injuries in some patients.
- In a study of 236 HCV patients on GP therapy, 61.9% experienced liver injury, with serious cases occurring in 3.8% of participants.
- Age and total bilirubin levels were identified as key risk factors, and adding ursodeoxycholic acid (UDCA) helped reduce liver damage in patients with significant bilirubin elevation.
Article Abstract
Although glecaprevir/pibrentasvir (GP) therapy is recommended as a first-line treatment for hepatitis C virus (HCV) infection, serious drug-induced liver injury occasionally develops. The present study aimed to elucidate real-world risk factors for GP-induced liver injury and to evaluate the efficacy of add-on ursodeoxycholic acid (UDCA) for liver injury. We analyzed 236 HCV patients who received GP therapy. GP-induced liver injury was defined as any elevation to grade ≥ 1 in total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), or γ-glutamyl transferase (γ-GT) during treatment without other cause. The frequency of GP-induced liver injury was 61.9% (146/236). Serious elevation to grade ≥ 3 in TB, AST, ALT, ALP, and γ-GT was identified in 3.8% (9/236), 0%, 0%, 0%, and 0.4% (1/209), respectively. Therapy discontinuation and dose reduction were seen in one patient each. Multivariate analysis revealed age and TB as independent risk factors for GP-induced liver injury. In patients with grade ≥ 2 hyperbilirubinemia, TB after onset significantly decreased in the add-on UDCA group but not in the no UDCA group. Careful attention to GP-induced liver injury is warranted for elderly patients with cirrhosis. Add-on UDCA could suppress the aggravation of GP-induced liver injury.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962642 | PMC |
| http://dx.doi.org/10.3390/v15020489 | DOI Listing |
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