AI Article Synopsis
- Venezuelan, western, and eastern equine encephalitic alphaviruses (VEEV, WEEV, EEEV) are dangerous arboviruses that primarily affect horses but can also severely impact humans, with no approved vaccines or treatments currently available.
- The urgency to address these viruses is highlighted by recent outbreaks, such as the 2019 EEE surge in the U.S., which resulted in numerous fatalities, indicating the potential biothreat of aerosolized VEEV and EEEV.
- This review discusses recent advancements in small molecule inhibitors for these viruses, categorizes them based on their mechanisms, and outlines important milestones in drug development and considerations for moving these compounds through clinical stages.
Article Abstract
Venezuelan, western, and eastern equine encephalitic alphaviruses (VEEV, WEEV, and EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause significant harm to infected humans. Currently, human alphavirus infection and the resulting diseases caused by them are unmitigated due to the absence of approved vaccines or therapeutics for general use. These circumstances, combined with the unpredictability of outbreaks-as exemplified by a 2019 EEE surge in the United States that claimed 19 patient lives-emphasize the risks posed by these viruses, especially for aerosolized VEEV and EEEV which are potential biothreats. Herein, small molecule inhibitors of VEEV, WEEV, and EEEV are reviewed that have been identified or advanced in the last five years since a comprehensive review was last performed. We organize structures according to host- versus virus-targeted mechanisms, highlight cellular and animal data that are milestones in the development pipeline, and provide a perspective on key considerations for the progression of compounds at early and later stages of advancement.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958955 | PMC |
| http://dx.doi.org/10.3390/v15020413 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Drug-assisted White Light Generation via Self-assembly.
Chem Asian J
January 2025
IISER Bhopal Department of Chemistry, Chemistry, Indore By-pass Road, Bhauri, 462066, Bhopal, INDIA.
White-light generation using small organic molecules has gained significant attention from researchers working on the interface of supramolecular chemistry and organic materials. Self-assembled multi-chromophoric materials utilizing a drug molecule and microenvironment-sensitive intramolecular charge transfer dye as an emitter offer the possibility of tunable emission. In this investigation, we focused on white light generation via the combination of a polarity-sensitive red-emitting styryl chromone (SC) and a blue-emitting anticancer and psychotherapeutic drug Norharmane (NHM) in a self-assembled micellar system.
View Article and Find Full Text PDFWater-regulated viscosity-plasticity phase transitions in a peptide self-assembled muscle-like hydrogel.
Nat Commun
January 2025
Department of Chemistry, School of Science, Westlake University, Hangzhou, Zhejiang Province, China.
The self-assembly of small molecules through non-covalent interactions is an emerging and promising strategy for building dynamic, stable, and large-scale structures. One remaining challenge is making the non-covalent interactions occur in the ideal positions to generate strength comparable to that of covalent bonds. This work shows that small molecule YAWF can self-assemble into a liquid-crystal hydrogel (LCH), the mechanical properties of which could be controlled by water.
View Article and Find Full Text PDFXanthium strumarium/gelatin methacryloyl based hydrogels with anti-inflammatory and antioxidant properties for diabetic wound healing via akt/mtor pathway.
Int J Biol Macromol
January 2025
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, Guangdong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 999077, China. Electronic address:
Chronic wound healing is often hindered by long-term inflammation and redox imbalance. Herbal medicine, with its rich medicinal components such as polysaccharides, flavonoids, phenolic acids, and small-molecule nutrients, has gained attention for its anti-inflammatory and antioxidant properties. Xanthium strumarium (XS) is a potent anti-inflammatory herb that has shown promise in treating conditions like rhinitis and may have specific benefits for chronic skin wounds.
View Article and Find Full Text PDFThe novel use of the CFTR corrector C17 in muscular dystrophy: Pharmacological profile and in vivo efficacy.
Biochem Pharmacol
January 2025
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy,. Electronic address:
Sarcoglycanopathies are rare forms of severe muscular dystrophies currently without a therapy. Mutations in sarcoglycan (SG) genes cause the reduction or absence of the SG-complex, a tetramer located in the sarcolemma that plays a protective role during muscle contraction. Missense mutations in SGCA, which cause α-sarcoglycanopathy, otherwise known as LGMD2D/R3, lead to folding defective forms of α-SG that are discarded by the cell quality control.
View Article and Find Full Text PDFAcute myeloid leukemia with t(8;21) translocation: Molecular pathogenesis, potential therapeutics and future directions.
Biochem Pharmacol
January 2025
Department of Hematology of First Affiliated Hospital, and Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, China. Electronic address:
Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive blood cancer. Genetic abnormalities, such as the t(8;21) rearrangement, play a significant role in AML onset. This rearrangement leads to the formation of the RUNX1/RUNX1T1 fusion protein, disrupting gene regulation and genomic stability, ultimately causing full-blown leukemia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!