AI Article Synopsis
- COBRAs are a promising universal influenza vaccine that needs further study on how they trigger immune responses with different adjuvants.
- In studies, various adjuvants, including AddaVax and AddaS03, were tested with two COBRAs specific to H1 and N1 subtypes.
- AddaS03 was found to be the most effective adjuvant, producing high levels of antibodies in response to the vaccine candidates, particularly effective against the 2009 H1N1 virus.
Article Abstract
Computationally optimized broadly reactive antigens (COBRAs) are a next-generation universal influenza vaccine candidate. However, how these COBRAs induce antibody responses when combined with different adjuvants has not previously been well-characterized. Therefore, we performed in vivo studies with an HA-based H1 COBRA, Y2, and an NA-based N1 COBRA, N1-I, to assess this effect for the H1N1 subtype. We tested the adjuvants AddaVax, AddaS03, CpG, and Alhydrogel. AddaS03 performed the best, eliciting high IgG titers and hemagglutination inhibition (HAI) activity for Y2 immunizations. Interestingly, serum antibody epitopes were relatively similar across adjuvant groups. Moreover, following N1-I immunization with these adjuvants, AddaS03 also elicited the highest IgG and neuraminidase inhibition (NAI) titers against the 2009 pandemic virus, A/California/07/2009 (A/CA/09). These results inform adjuvant selection efforts for H1 and N1 COBRA HA and NA antigens in a mouse model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960755 | PMC |
| http://dx.doi.org/10.3390/v15020347 | DOI Listing |
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