AI Article Synopsis
- Antimicrobial drugs, which include antibiotics, antifungals, antiparasitics, and antivirals, are crucial for treatment but can impact the central nervous system (CNS) in various ways.
- These drugs also alter gut microbiota, influencing the gut-microbiota-brain axis and affecting brain functions and behaviors.
- Zebrafish are becoming an important model for studying these effects, and this review highlights recent findings and suggests future research directions in understanding antimicrobial drugs' impact on brain and behavior using zebrafish.
Article Abstract
Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut-microbiota-brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish () emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964482 | PMC |
| http://dx.doi.org/10.3390/vetsci10020096 | DOI Listing |
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