In recent years, the rapid development of deep learning approaches has paved the way to explore the underlying factors that explain the data. In particular, several methods have been proposed to learn to identify and disentangle these underlying explanatory factors in order to improve the learning process and model generalization. However, extracting this representation with little or no supervision remains a key challenge in machine learning. In this paper, we provide a theoretical outlook on recent advances in the field of unsupervised representation learning with a focus on auto-encoding-based approaches and on the most well-known supervised disentanglement metrics. We cover the current state-of-the-art methods for learning disentangled representation in an unsupervised manner while pointing out the connection between each method and its added value on disentanglement. Further, we discuss how to quantify disentanglement and present an in-depth analysis of associated metrics. We conclude by carrying out a comparative evaluation of these metrics according to three criteria, (i) modularity, (ii) compactness and (iii) informativeness. Finally, we show that only the Mutual Information Gap score (MIG) meets all three criteria.
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http://dx.doi.org/10.3390/s23042362 | DOI Listing |
Comput Biol Med
December 2024
Institute for Imaging, Data and Communications (IDCOM), School of Engineering, University of Edinburgh, Edinburgh, EH9 3FB, UK.
Artifacts are a common problem in physiological time series collected from intensive care units (ICU) and other settings. They affect the quality and reliability of clinical research and patient care. Manual annotation of artifacts is costly and time-consuming, rendering it impractical.
View Article and Find Full Text PDFJ Neurosci
December 2024
Neurobiology Laboratory, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, North Carolina 27713, USA
Perineuronal nets (PNNs) are a specialized extracellular matrix that surround certain populations of neurons, including (inhibitory) parvalbumin (PV) expressing-interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hippocampus. PNNs are thought to regulate synaptic plasticity by stabilizing synapses and as such, could regulate learning and memory. Most often, PNN functions are queried using enzymatic degradation with chondroitinase, but that approach does not differentiate PNNs on CA2 neurons from those on adjacent PV cells.
View Article and Find Full Text PDFSci Rep
December 2024
Rotterdam School of Management, Erasmus University, Burgemeester Oudlaan 50, 3062 PA, Rotterdam, The Netherlands.
Does competition increase cheating? This question has been investigated by both psychologists and economists in the past and received conflicting answers. Notably, prior experimental work compared how people behaved under competitive and non-competitive tasks that were associated with different levels of uncertainty about the reward that people would receive. We aim to experimentally disentangle the effect of competition from the effects of uncertain rewards.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzębiec, Poland.
Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this association are not well known. Here, we investigated the effects of advanced maternal age on offspring health and behavior in two genetically divergent mouse strains: the BTBR T Itpr3/J (BTBR) mouse model of idiopathic autism, and the C57BL/6 J (B6) control strain, as a model of genetic variability.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Introduction: Diffusion-weighted magnetic resonance imaging (dMRI) is sensitive to the microstructural properties of brain tissues and shows great promise in detecting the effects of degenerative diseases. However, many approaches analyze single measures averaged over regions of interest without considering the underlying fiber geometry.
Methods: We propose a novel macrostructure-informed normative tractometry (MINT) framework to investigate how white matter (WM) microstructure and macrostructure are jointly altered in mild cognitive impairment (MCI) and dementia.
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