The role of extracellular ATP and P2X receptors in the pathogenesis of HIV-1.

Curr Opin Pharmacol

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Published: April 2023

AI Article Synopsis

Article Abstract

Human Immunodeficiency Virus Type 1 (HIV-1) causes a chronic, incurable infection associated with chronic inflammation despite virologic suppression on antiretroviral therapy (ART). This chronic inflammation underlies significant comorbidities, including cardiovascular disease, neurocognition decline, and malignancies. The mechanisms of chronic inflammation have been attributed, in part, to the role of extracellular ATP and P2X-type purinergic receptors that sense damaged or dying cells and undergo signaling responses to activate inflammation and immunomodulation. This review describes the current literature on the role of extracellular ATP and P2X receptors in HIV-1 pathogenesis, describing the known intersection with the HIV-1 life cycle in mediating immunopathogenesis and neuronal disease. The literature supports key roles for this signaling mechanism in cell-to-cell communication and in activating transcriptional changes that impact the inflammatory state leading to disease progression. Future studies must characterize the numerous functions of ATP and P2X receptors in HIV-1 pathogenesis to inform future therapeutic targeting.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023410PMC
http://dx.doi.org/10.1016/j.coph.2023.102358DOI Listing

Publication Analysis

Top Keywords

role extracellular
12
extracellular atp
12
atp p2x
12
p2x receptors
12
chronic inflammation
12
receptors hiv-1
8
hiv-1 pathogenesis
8
hiv-1
5
atp
4
receptors
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!