4-Picoline derivatives are converted to the corresponding aryl picolyl sulfones upon treatment with aryl sulfonyl chlorides and EtN in the presence of catalytic DMAP. The reaction proceeds smoothly for a variety of alkyl and aryl picolines using a range of aryl sulfonyl chlorides. The reaction is believed to involve -sulfonyl 4-alkylidene dihydropyridine intermediates and results in formal sulfonylation of unactivated picolyl C-H bonds.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028608 | PMC |
| http://dx.doi.org/10.1021/acs.joc.3c00017 | DOI Listing |
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