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http://dx.doi.org/10.1093/pm/pnad024 | DOI Listing |
Nat Metab
January 2025
Centre for Orthopaedic Research, Medical School of the University of Western Australia, Nedlands, Western Australia, Australia.
Intercellular mitochondria transfer is an evolutionarily conserved process in which one cell delivers some of their mitochondria to another cell in the absence of cell division. This process has diverse functions depending on the cell types involved and physiological or disease context. Although mitochondria transfer was first shown to provide metabolic support to acceptor cells, recent studies have revealed diverse functions of mitochondria transfer, including, but not limited to, the maintenance of mitochondria quality of the donor cell and the regulation of tissue homeostasis and remodelling.
View Article and Find Full Text PDFAnesthesiology
January 2025
Division of Anesthesia, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Background: Effective pain recognition and treatment in perioperative environments reduce length of stay and decrease risk of delirium and chronic pain. We sought to develop and validate preliminary computer vision-based approaches for nociception detection in hospitalized patients.
Methods: Prospective observational cohort study using red-green-blue camera detection of perioperative patients.
Violence Against Women
January 2025
Department of Nursing and Midwifery, University of Birmingham, Birmingham, UK.
Domestic violence and abuse (DVA) is a global problem that affects approximately one in four women in their lifetime. An area of unexplored research is how women use a range of strategies to honor resistance, manage the risk, avoid abuse, and cope with the pain of DVA. Art-based methodology and interpretative phenomenological analysis approaches were used which determined seven strategies employed by women in order to survive DVA: apparent compliance; maintaining a sense of self; knowing boundaries; keeping hope in sight; imagining freedom; degrees of rebellion; and denial.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India.
Microneedles (MNs) appear as a transformative and minimally invasive platform for transdermal drug delivery, representing a highly promising strategy in wound healing therapeutics. This technology, entailing the fabrication of micron-scale needle arrays, enables the targeted and efficient delivery of bioactive agents into the epidermal and dermal layers without inducing significant pain or discomfort. The precise penetration of MNs facilitates localized and sustained drug release, which significantly enhances tissue regeneration and accelerates wound closure.
View Article and Find Full Text PDFFront Psychol
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, United States.
We introduce two Korean-named yet transcultural feelings, and , to fill gaps in neuroscientific understanding of mammalian bondedness, loss, and aggression. is a visceral sense of connectedness to a person, place, or thing that may arise after proximity, yet does not require intimacy. The brain opioid theory of social attachment (BOTSA) supports the idea that involves increased activity of enkephalins and beta-endorphins.
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