AI Article Synopsis
- A new method is introduced for linking sugars using a non-classical -saccharide linkage through radical additions to Michael acceptors.
- C(sp)-S cleaved glycosyl thianthrenium salts are created to serve as effective glycosyl radical agents in this process.
- This technique allows for the efficient synthesis of β-glycosyl substituted unnatural amino acids and enables modifications of peptides later in the synthesis process.
Article Abstract
Herein, a non-classical -saccharide linkage is reported a C5 radical of pentose or C6 radical of hexose addition to Michael acceptors. C(sp)-S cleaved glycosyl thianthrenium salts are developed as the glycosyl radical agents. The reaction provides an efficient toolkit to synthesize β-glycosyl substituted unnatural amino acids as well as for the late-stage -saccharide modification of peptides.
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| http://dx.doi.org/10.1039/d2cc06653j | DOI Listing |
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