AI Article Synopsis
- Nicotinamide mononucleotide (NMN), particularly its active form β-NMN, is crucial for producing the coenzyme NAD and is important in various biological processes.
- β-NMN has potential applications in anti-aging and treating metabolic diseases, prompting further research into its large-scale production.
- The review focuses on the methods of synthesizing β-NMN, specifically biosynthesis due to its efficiency and fewer side effects, while also exploring ways to enhance production strategies through synthetic biology.
Article Abstract
Nicotinamide mononucleotide (NMN) is one of the key precursors of coenzyme Ⅰ (NAD). NMN exists widely in a variety of organisms, and β isomer is its active form. Studies have shown that β-NMN plays a key role in a variety of physiological and metabolic processes. As a potential active substance in anti-aging and improving degenerative and metabolic diseases, the application value of β-NMN has been deeply explored, and it is imminent to achieve large-scale production. Biosynthesis has become the preferred method to synthesize β-NMN because of its high stereoselectivity, mild reaction conditions, and fewer by-products. This paper reviews the physiological activity, chemical synthesis as well as biosynthesis of β-NMN, highlighting the metabolic pathways involved in biosynthesis. This review aims to explore the potential of improving the production strategy of β-NMN by using synthetic biology and provide a theoretical basis for the research of metabolic pathways as well as efficient production of β-NMN.
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| http://dx.doi.org/10.13345/j.cjb.220880 | DOI Listing |
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