AI Article Synopsis
- * Various strategies for studying T3Es include analyzing where they localize in host cells, testing their ability to cause disease, performing biochemical assays, and utilizing large-scale omics techniques like transcriptomics and interactomics.
- * The research examines the case of a plant disease-causing bacterial species complex (RSSC) to highlight the latest advancements in understanding how these effectors work, which could lead to better methods for controlling these phytopathogens.
Article Abstract
The type III secretion system (T3SS) is a well-studied pathogenicity determinant of many bacteria through which effectors (T3Es) are translocated into the host cell, where they exercise a wide range of functions to deceive the host cell's immunity and to establish a niche. Here we look at the different approaches that are used to functionally characterize a T3E. Such approaches include host localization studies, virulence screenings, biochemical activity assays, and large-scale omics, such as transcriptomics, interactomics, and metabolomics, among others. By means of the phytopathogenic species complex (RSSC) as a case study, the current advances of these methods will be explored, alongside the progress made in understanding effector biology. Data obtained by such complementary methods provide crucial information to comprehend the entire function of the effectome and will eventually lead to a better understanding of the phytopathogen, opening opportunities to tackle it.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945535 | PMC |
| http://dx.doi.org/10.3389/fmicb.2023.1113442 | DOI Listing |
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