Objective: Variants in the glucocerebrosidase () gene are the most common and significant risk factor for Parkinson's disease (PD). However, the impact of variants on PD disease progression in the Chinese population remains unclear. This study aimed to explore the significance of status on motor and cognitive impairment in a longitudinal cohort of Chinese patients with PD.
Methods: The entire gene was screened by long-range polymerase chain reaction (LR-PCR) and next generation sequencing (NGS). A total of 43 -related PD (-PD) and 246 non--mutated PD (NM-PD) patients with complete clinical data at baseline and at least one follow-up were recruited for this study. The associations of genotype with rate of motor and cognitive decline, as measured by Unified PD Rating Scale (UPDRS) motor and Montreal Cognitive Assessment (MoCA), were assessed by linear mixed-effect models.
Results: The estimated (standard error, SE) UPDRS motor [2.25 (0.38) points/year] and MoCA [-0.53 (0.11) points/year] progression rates in the -PD group were significantly faster than those in the NM-PD group [1.35 (0.19); -0.29 (0.04) points/year; respectively]. In addition, the -PD group showed significantly faster estimated (SE) bradykinesia [1.04 (0.18) points/year], axial impairment [0.38 (0.07) points/year], and visuospatial/executive [-0.15 (0.03) points/year] progression rates than the NM-PD group [0.62 (0.10); 0.17 (0.04); -0.07 (0.01) points/year; respectively].
Conclusion: -PD is associated with faster motor and cognitive decline, specifically greater disability in terms of bradykinesia, axial impairment, and visuospatial/executive function. Better understanding of -PD progression may help predict prognosis and improve clinical trial design.
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| http://dx.doi.org/10.3389/fnagi.2023.1091919 | DOI Listing |
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