Background And Purpose: Studies have shown that matrix metalloproteinase (MMP-2,3,9) plays an important role in the pathologic process of ischemic stroke (IS). The aim of this study was to investigate the relationship between C1306T, 1612-5A/6A, C-1562T polymorphisms of -2,3,9 genes and IS in Chinese Han population.
Methods: The polymorphisms of -2(C1306T), -3(1612-5A/6A), -9(C-1562T) gene were detected by PCR-RFLP and SNaPshot sequencing. Then, stratified analysis was used to study the relationship between IS subtypes and polymorphisms.
Results: For the gene C1306T polymorphism, TT genotype and T allele were significantly associated with a reduced risk of IS ( = 0.015, = 0.003, respectively). T allele was significantly associated with a reduced risk of small artery occlusion (SAO) subtype compared with the control group ( = 0.012, OR = 0.550, 95% CI = 0.065-1.291). For the gene-1612 (5A/6A) polymorphism, 5A/5A genotype was significantly increased in the IS group ( = 0.011, OR = 0.370, 95% CI = 0.168-0.814), especially in the large-artery atherosclerosis (LAA) subtype ( = 0.001, OR = 2.345) as compared to the control group.
Conclusion: Our study suggested that the T allele of -2 may be a protective factor of IS, especially in SAO subtype, while the 5A/5A gene of -3 may increase the risk of IS, especially in LAA subtype in Chinese Han population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951599 | PMC |
| http://dx.doi.org/10.2147/IJGM.S395416 | DOI Listing |
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