Targeting β-glucans, vital components of the cell wall.

Front Immunol

Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Published: February 2023

β-glucan is the most abundant polysaccharide in the cell wall of , which has attracted extensive attention because of its unique immunobiological characteristics. β-glucan binds to various cell surface receptors, which produces an inflammatory response and accounts for its immune effects. A deeper comprehension of the processes by β-glucan recognizes its receptors, activates related signaling pathways, and regulates immunity as required. Such understanding will provide a basis for developing new therapies against . Herein, we briefly review the structural composition of β-glucans as a vital component of the cell wall, the host immunity mediated by β-glucans after their recognition, and discuss opportunities for the development of new strategies to combat .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947646PMC
http://dx.doi.org/10.3389/fimmu.2023.1094464DOI Listing

Publication Analysis

Top Keywords

cell wall
12
β-glucans vital
8
targeting β-glucans
4
vital components
4
cell
4
components cell
4
wall β-glucan
4
β-glucan abundant
4
abundant polysaccharide
4
polysaccharide cell
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!