AI Article Synopsis
- The study aimed to explore the relationship between genetic inhibition of tumor necrosis factor receptor 1 (TNFR1) and the risk of periodontitis.
- Genetic data from a large sample were analyzed to assess whether TNFR1 inhibition influences periodontitis, utilizing variants linked to C-reactive protein.
- Results showed no significant effect of TNFR1 inhibition on periodontitis risk, indicating that this approach may not be effective for reducing its incidence.
Article Abstract
Aim: To investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis.
Materials And Methods: Genetic instruments were selected from the vicinity of TNFR superfamily member 1A (TNFRSF1A) gene (chromosome 12; base pairs 6,437,923-6,451,280 as per GRCh37 assembly) based on their association with C-reactive protein (N= 575,531). Summary statistics of these variants were obtained from a genome-wide association study (GWAS) of 17,353 periodontitis cases and 28,210 controls to estimate the effect of TNFR1 inhibition on periodontitis using a fixed-effects inverse method.
Results: Considering rs1800693 as an instrument, we found no effect of TNFR1 inhibition on periodontitis risk (Odds ratio (OR) scaled per standard deviation increment in CRP: 1.57, 95% confidence interval (CI): 0.38;6.46). Similar results were derived from a secondary analysis that used three variants (rs767455, rs4149570, and rs4149577) to index TNFR1 inhibition.
Conclusions: We found no evidence of a potential efficacy of TNFR1 inhibition on periodontitis risk.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949605 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1094175 | DOI Listing |
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