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An unusual case of smoldering AML with prolonged indolent clinical course and spontaneous remission in the terminal phase.
Med Oncol
December 2009
KBC Bezanijska kosa, 11080, Beograd, Serbia.
An unusual case of acute myeloblastic leukemia (AML) with indolent clinical course and spontaneous remission in the terminal phase is described. A 63-year-old male has been diagnosed to suffer from AML, subtype M2. Chromosomal analysis showed 46,XY,del(6)(q21).
View Article and Find Full Text PDFAdult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes.
Int J Cancer
August 1999
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Adult T-cell leukemia (ATL) is a T-cell malignancy caused by human T-cell-leukemia-virus-I (HTLV-I) infection. ATL comprises 4 clinical forms: acute, chronic, smoldering and lymphoma types. ATL is usually resistant to conventional chemotherapy and has a relatively poor prognosis; however, the resistance mechanisms remain undetermined.
View Article and Find Full Text PDFDetection of neoplastic clone in the hypoplastic and recovery phases preceding acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain gene.
J Pediatr Hematol Oncol
August 1995
Department of Pediatrics, Akita University School of Medicine, Japan.
This study assessed the clonality of hypoplastic and subsequent recovery phases before the development of overt leukemia by molecular genetic analysis. We describe a boy who had transient granulocytopenia and anemia before the development of acute lymphoblastic leukemia (ALL). Initially, his bone marrow was hypocellular with 23.
View Article and Find Full Text PDFHigh degree of myeloid differentiation and granulocytosis is associated with t(8;21) smoldering leukemia.
Leukemia
July 1995
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
The t(8;21) is a frequent chromosome abnormality in acute myeloid leukemia (AML), particularly associated with M2 of the French-American-British (FAB) classification, but also found in a few patients with myelodysplastic syndrome (MDS). The two genes involved in the t(8;21) have been recently isolated and the cDNA of the AML1/ETO fusion gene identified. We have investigated a series of AML and MDS patients by a reverse transcriptase-polymerase chain reaction (RT-PCR) and analyzed the clinical and laboratory features of leukemia with t(8;21).
View Article and Find Full Text PDFParoxysmal nocturnal hemoglobinuria with myelofibrosis: progression to acute myeloblastic leukemia.
Leuk Lymphoma
December 1993
First Department of Internal Medicine, Niigata University, School of Medicine, Japan.
A 58-year-old male was diagnosed as having paroxysmal nocturnal hemoglobinuria (PNH) with myelofibrosis in 1984. The administration of hydroxyurea and low dose splenic irradiation were initiated for abdominal distention due to splenomegaly in 1987. In May 1990 the patient developed smouldering acute myeloblastic leukemia (AML); and the blasts proliferated in response to G-CSF administered for refractory pneumonia.
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