AI Article Synopsis
- Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe inflammatory disorder where the immune system goes into overdrive, causing serious symptoms and affecting multiple organs.
- The condition is characterized by symptoms like fever, enlarged spleen and liver, low blood cell counts, and high levels of certain proteins in the blood.
- While HLH is usually seen in children due to genetic reasons, this case highlights a 71-year-old patient whose HLH was linked to the progression of chronic lymphocytic leukemia (CLL), which is uncommon.
Article Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an acute, rare systemic hyperinflammatory disorder caused by a dysregulated immune cell function and massive cytokine release, often leading to multiple organ involvement and failure. Fever, hepatosplenomegaly, cytopenia, elevated liver enzymes, hypertriglyceridemia, and hyperferritinemia are the hallmarks of the disease. Its primary (genetic) form is typically observed in pediatric patients and its secondary, acquired form is seen in adult patients with an underlying autoimmune, malignant, or infectious disease. It is not frequently reported in patients with chronic lymphocytic leukemia (CLL) without an infectious or pharmacological trigger. We present a case of a 71-year-old patient with hemophagocytic lymphohistiocytosis due to the progression of chronic lymphocytic leukemia.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949745 | PMC |
| http://dx.doi.org/10.7759/cureus.34128 | DOI Listing |
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