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Multidomain cognitive training increases physical activity in people with Parkinson's disease with mild cognitive impairment. | LitMetric

Multidomain cognitive training increases physical activity in people with Parkinson's disease with mild cognitive impairment.

Parkinsonism Relat Disord

German Center of Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany; IB-Hochschule, Paulinenstr. 45, 70178, Stuttgart, Germany. Electronic address:

Published: August 2023

AI Article Synopsis

  • Cognitive impairment in Parkinson's disease (PD), particularly in mild cognitive impairment (PD-MCI) patients, is linked to lower physical activity, but the impact of cognitive training (CT) on movement in everyday settings is not well understood.
  • An exploratory study involving 18 patients with PD-MCI assessed the short-term effects of either a six-week cognitive training or physical training on physical activity measured with wearable accelerometers before and after the intervention.
  • Results indicated that those in the cognitive training group experienced greater increases in active behavior, which correlated with improvements in executive functioning, while lower working memory and difficulties with daily activities were linked to higher sedentary behavior.

Article Abstract

Introduction: Cognitive impairment in Parkinson's disease (PD), especially in patients with mild cognitive impairment (PD-MCI), coincides with less physical activity. Cognitive trainings (CT) have been found to promote laboratory environment-based movement. Knowledge about their effect in natural home-based environment, reflecting everyday function, is sparse. This explorative study investigated short-term effects of CT on physical activity assessed by home-based accelerometry, and its relation to change of cognitive function over time and non-cognitive outcomes in patients with PD-MCI. Cognitive and non-cognitive correlates of movement parameters at pretest were evaluated as well.

Methods: Eighteen patients with PD-MCI of the TrainParC study were analyzed. Those patients received either a 6-week multidomain group CT or physical training (PT). Physical activity and sedentary behavior were assessed with wearable accelerometers worn up to seven days pre- and post-training.

Results: Patients in the CT group displayed significantly greater increases in active periods after training than patients assigned to PT. In the CT group, increases in executive functioning were associated with increases in active periods and decreases in active mean bout length after training. At pretest, reduced working memory correlated with longer sedentary mean bout length, and impairment in activities of daily living (ADL) correlated with a higher number of sedentary periods.

Conclusion: Study data revealed that CT can increase physical activity in patients with PD-MCI, possibly due to effects on executive functions, which needs further investigation in larger sample sizes. Lower working memory performance and ADL impairment might be associated with a more inactive lifestyle in patients with PD-MCI.

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Source
http://dx.doi.org/10.1016/j.parkreldis.2023.105330DOI Listing

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