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Models for Implant-Induced Capsular Contracture Post Breast Cancer Surgery.
Bull Math Biol
December 2023
Department of Mathematics, University of British Columbia, Vancouver, BC, V6T 1Z2, Canada.
Capsular contracture is a painful deformation of scar-tissue that may form around an implant in post-breast cancer reconstruction or cosmetic surgery. Inflammation due to surgical trauma or contamination in the tissue around the implant could account for recruitment of immune cells, and transdifferentiation of resident fibroblasts into cells that deposit abnormally thick collagen. Here we examine this hypothesis using a mathematical model for interacting macrophages, fibroblasts, myofibroblasts, and collagen.
View Article and Find Full Text PDFBreast implant-induced cutaneous lymphoma.
Int J Dermatol
September 2023
Department of Dermatology, Wayne State University School of Medicine, Detroit, MI, USA.
Matrix Metalloproteinase-9 as a Potential Biomarker in 631 Human Implant-Induced Fibrotic Capsules: Analysis and Biomarker Study.
Plast Reconstr Surg
October 2023
University Center for Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef.
Background: Capsular fibrosis (CF) often occurs around biomedical devices following implantation causing pain, discomfort, and device failure. Breast implantation remains among the most common medical procedures worldwide. Revealing specific genes that drive fibrotic deposition will help us to garner a better understanding of the pathophysiology of this disease and develop different strategies to combat it.
View Article and Find Full Text PDFSilicone implant-induced hypercalcemia is a rather rare pathological entity. There are only a few published reports on the topic. Here, we have reported a case of acute kidney injury in the background of hypercalcemia and elevated vitamin D level in a transgender patient with a history of silicone injections in the breast and buttocks for cosmetic purposes.
View Article and Find Full Text PDFStaged Chest Wall Reconstruction for Radiation-induced Costochondritis.
Plast Reconstr Surg Glob Open
August 2021
Department of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, Seo-gu, Busan, South Korea.
Costochondritis after breast reconstruction and radiation therapy is rarely reported. Moreover, it is difficult to diagnose using computed tomography and magnetic resonance imaging; as such, wound debridement and reconstruction must be performed in several stages. A 51-year-old woman was diagnosed with invasive cancer of the right breast, and she underwent nipple sparing mastectomy and direct-to-implant breast reconstruction in November 2007.
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