AI Article Synopsis

  • * Certain receptors (AHRs) are activated by these external factors and play a role in regulating skin cell function through the AKR1C3 gene, which is important for skin cell differentiation.
  • * A study found specific gene variations (SNPs) in AKR1C3 to be more common in Japanese psoriasis patients, especially in younger females, suggesting that these variations may lead to lower gene expression and contribute to the development of psoriasis by affecting how skin cells mature and function.

Article Abstract

The principal pathology of psoriasis is impaired skin barrier function, epidermal thickening, and granular layer loss. Exposure to extrinsic factors such as tobacco smoke and air pollutants is associated with the development of psoriasis. Aryl hydrocarbon receptors (AHRs) are activated by extrinsic factors associated with the development of psoriasis and act as transcriptional regulators. Expression of aldo-keto reductase (AKR) 1C3 in the epidermal spinous layer regulates epidermal keratinocyte differentiation via the AHR signaling pathway. We investigated whether single nucleotide polymorphisms (SNPs) in AKR1C3 are associated with the pathogenesis of psoriasis. The proportions of rs12529 G/C, C/C variants, and rs12387 A/A, A/G variants were twofold higher in Japanese psoriasis patients (n = 231) compared with a Japanese healthy cohort. The SNPs were significantly more common than the majority variants in female patients with disease onset ≤ 22 years of age. Patients with rs12529 G > C and rs12387 A > G SNPs exhibited significantly lower AKR1C3 expression and higher expression of late differentiation markers. In conclusion, AKR1C3 downregulation caused by rs12529 G > C and rs12387 A > G SNPs in the epidermis induces abnormal early differentiation of keratinocytes and skin barrier dysfunction, which may contribute to the genetic pathogenesis of psoriasis in young females.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968313PMC
http://dx.doi.org/10.1038/s41598-023-30464-8DOI Listing

Publication Analysis

Top Keywords

aldo-keto reductase
8
psoriasis patients
8
skin barrier
8
extrinsic factors
8
associated development
8
development psoriasis
8
pathogenesis psoriasis
8
rs12529 g > c
8
g > c rs12387
8
rs12387 a > g
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!