AI Article Synopsis
- The study investigates the predictive value of carbohydrate antigen 125 (CA125) levels in patients with stage D heart failure (HF), aiming to assess its ability to predict mortality and hospital readmissions.
- The researchers divided 176 HF patients into two groups based on CA125 levels above and below a median of 65.7 U/ml, finding that higher CA125 levels correlated with significantly increased mortality and rehospitalization rates within an 18-month follow-up period.
- The results concluded that elevated CA125 is a strong prognostic indicator for various adverse outcomes in stage D HF patients, suggesting its utility for enhancing risk assessment and management in this patient population.
Article Abstract
Background: The predictive value of carbohydrate antigen 125 (CA125) has not been examined in stage D heart failure (HF) patients, regardless of left ventricular ejection fraction (LVEF). We sought to quantify the prognostic usefulness in predicting death and HF readmission in this cohort.
Methods: According to CA125 levels above and below the median (65.7 U/ml), 176 stage D HF patients including more than half (50.6%) had LVEF > 40% were divided into 2 groups.
Results: A total of 106 (60.2%) deaths and 102 deaths due to the cardiovascular disease were identified. All-cause death/HF readmission and MACE occurred in 157 patients (89.2%) during 18 months (16-20) of follow-up. By the Kaplan-Meier method, subjects with CA125 ≥ 65.7 U/ml exhibited higher 1-year mortality rate (59.3% vs. 31.0%, P < 0.001) and 1-year death/HF rehospitalization rate (94.2% vs. 80.6%, P < 0.001). In univariate Cox analysis, CA125 (categorized) was a significant prognostic factor for all-cause death, cardiovascular mortality, death/HF readmission and MACE. Based on multivariate Cox analysis, elevated CA125 was still significant for all-cause death, cardiovascular mortality, death/HF readmission and MACE.
Conclusions: In stage D HF patients, elevated CA125 levels were highly predictive of all-cause death, cardiovascular mortality, all-cause death/HF readmission and MACE, which can be used for better risk stratification.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960178 | PMC |
| http://dx.doi.org/10.1186/s12872-023-03139-5 | DOI Listing |
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